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Glypican-3 (GPC3) is a protein that is encoded by the GPC3 gene. The protein encoded by this gene is a member of the glypican family. Glypicans are cell surface heparan sulfate proteoglycans composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. Glypican-3 plays a role in the control of cell division and growth regulation. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome.

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Glypican 3 immunostaining with BioMosaic antibody (clone 1G12) has utility for differentiating hepatocellular carcinoma (HCC) and dysplastic changes in cirrhotic livers; HCC stains with GPC3, while cirrhotic liver does not. Glypican-3 is also detected in a percentage of high-grade dysplastic macronodules, suggesting expression begins at the earliest stagies of malignant transformation.

Antibody products for IHC
Catalog Name Description  
B0025R Glypican-3 antibody, clone 1G12  25 microgram concentrate, 50  IHC tests  
B0134R Glypican-3 antibody, clone 1G12  7 ml, pre-diluted for IHC, 50 tests  
B0055R  Glypican-3 antibody, clone 1G12  250 microgram concentrate, 500  IHC tests  
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